Street Crime Units from Stratford Police, the Huron, Bruce, Grey and Perth County OPP worked together in seizing more than $50,000 worth of drugs in Huron East.
Police say the investigation was sparked by officers who pulled over a vehicle in Perth East on Tuesday when they found methamphetamines, cannabis and weapons.
The investigation led to officers carrying out a search warrant in Huron East where they uncovered more drugs.
Two people from Stratford and two from Huron East are facing a number of drugs and weapons charges as a result of the bust.