Police say three people have died and another has life-threatening injuries after a collision in Huron East.

First responders were called out to Brussels Line, between Cardiff Road and Browntown Road, around 7:45 Monday morning after a single-vehicle collision involving a pickup truck.

They say a male driver and two passengers were pronounced dead at the scene while a fourth passenger was airlifted to a London hospital with life-threatening injuries.

Police say the identities of the driver and passengers are being withheld pending notification of next-of-kin.

Brussels Line between Cardiff Road and Browntown Road was closed for several hours to facilitate the investigation and it reopened just after 5 p.m.

An investigation into the collision continues.